The Trouble with Knowing: Wikipedian consensus and the political design of encyclopedic media

Encyclopedias are interfaces between knowing and the unknown. They are devices that negotiate the middle ground between incompatible knowledge systems while also performing as dream machines that explore the political outlines of an enlightened society. Building upon the insights from critical feminist theory, media archaeology, and science and technology studies, the dissertation investigates how utopian and impossible desires of encyclopedic media have left a wake of unresolvable epistemological crises. In a 2011 survey of editors of the online encyclopedia Wikipedia, it was reported that 87 per cent of Wikipedians identified as men. This statistic flew in the face of Wikipedias utopian promise that it was an encyclopedia that anyone can edit. Despite the early optimism and efforts to reduce this disparity, Wikipedias parent organization acknowledged its inability to significantly make Wikipedia more equitable. This matter of concern raised two questions: What kinds of knowing subjects is Wikipedia designed to cultivate and what does this conflict over who is included and excluded within Wikipedia tell us about the utopian dreams that are woven into encyclopedic media? This dissertation argues that answering these troubling questions requires an examination of the details of the present, but also the impossible desires that Wikipedia inherited from its predecessors. The analysis of these issues begins with a genealogy of encyclopedias, encyclopedists, encyclopedic aesthetics, and encyclopedisms. It is followed by an archeology of the twentieth century deployment of consensus as an encyclopedic and political program. The third part examines how Wikipedia translated the imaginary ideal of consensus into a cultural technique. Finally, the dissertation mobilizes these analyses to contextualize how consensus was used to limit the dissenting activities of Wikipedia's Gender Gap Task Force. The dissertation demonstrates that the desire and design of encircling knowledge through consensus cultivated Wikipedias gender gap. In this context, if encyclopedic knowledge is to remain politically and culturally significant in the twenty-first century, it is necessary to tell a new story about encyclopedic media. It must be one where an attention to utopian imaginaries, practices, and techniques not only addresses how knowledge is communicated but also enables a sensitivity to the question of who can know

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Genetic factors have been implicated in stroke risk but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) in ischemic stroke and its subtypes in 3,548 cases and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 cases and 6,281 controls. We replicated reported associations between variants close to PITX2 and ZFHX3 with cardioembolic stroke, and a 9p21 locus with large vessel stroke. We identified a novel association for a SNP within the histone deacetylase 9(HDAC9) gene on chromosome 7p21.1 which was associated with large vessel stroke including additional replication in a further 735 cases and 28583 controls (rs11984041, combined P = 1.87×10−11, OR=1.42 (95% CI) 1.28-1.57). All four loci exhibit evidence for heterogeneity of effect across the stroke subtypes, with some, and possibly all, affecting risk for only one subtype. This suggests differing genetic architectures for different stroke subtypes

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc

Precision of personal sampling of respirable dust in coal mines /

Bibliography: p. 11.Mode of access: Internet

Development of quality indicators for endoscopic eradication therapies in Barrett's esophagus: the TREAT-BE (Treatment with Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) Consortium

Am J Gastroenterol advance online publication, 1 June 2017; doi:10.1038/ajg.2017.16